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Charles River Laboratories
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Inotiv
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Image Search Results
Journal: The FASEB Journal
Article Title: Obesity reduces mammary epithelial cell TGFβ1 activity through macrophage‐mediated extracellular matrix remodeling
doi: 10.1096/fj.202000228RR
Figure Lengend Snippet: Obesity decreases downstream targets of the TGFβ1 pathway in mammary epithelial cells. A, Weight of 3‐week‐old FVB/N or 8‐week‐old C57BL/6 female mice fed a control diet (CD, n = 6) or high‐fat diet (HFD, n = 6; * P < .05; repeated measures ANOVA with Sidak's multiple comparison test). B, Percent pSMAD2 + cells in mouse mammary ducts (n = 5 mice/group). C, Percent SMAD4 + cells in mouse mammary ducts (n = 5 mice/group). D, Weight of 8‐week‐old (adult) FVB/N female mice fed CD or HFD for 16 weeks (n = 5 mice/group). E, Percent pSMAD2 + cells in mammary ducts of adult FVB/N mice (n = 5 mice/group). F, TGFβ1 expression in mouse mammary ducts (n = 5 mice/group). G, Fold change of expression of TGFβ1 and TGFβRII relative to HPGRT in epithelial cells isolated from mouse mammary glands (n = 3 mice/group). H, Percent pSMAD2 + cells in breast ducts of women (n = 6 tissue samples/group). I, TGFβ1 expression in human breast ducts (n = 5 tissue samples/group). Data analyzed with Student's t test, mean ± SEM. Magnification bar = 50 µm
Article Snippet: For obesity studies, 3‐week‐old FVB/N or
Techniques: Control, Comparison, Expressing, Isolation
Journal: The FASEB Journal
Article Title: Obesity reduces mammary epithelial cell TGFβ1 activity through macrophage‐mediated extracellular matrix remodeling
doi: 10.1096/fj.202000228RR
Figure Lengend Snippet: Obesity decreases downstream targets of the TGFβ1 pathway in mammary epithelial cells. A, Weight of 3‐week‐old FVB/N or 8‐week‐old C57BL/6 female mice fed a control diet (CD, n = 6) or high‐fat diet (HFD, n = 6; * P < .05; repeated measures ANOVA with Sidak's multiple comparison test). B, Percent pSMAD2 + cells in mouse mammary ducts (n = 5 mice/group). C, Percent SMAD4 + cells in mouse mammary ducts (n = 5 mice/group). D, Weight of 8‐week‐old (adult) FVB/N female mice fed CD or HFD for 16 weeks (n = 5 mice/group). E, Percent pSMAD2 + cells in mammary ducts of adult FVB/N mice (n = 5 mice/group). F, TGFβ1 expression in mouse mammary ducts (n = 5 mice/group). G, Fold change of expression of TGFβ1 and TGFβRII relative to HPGRT in epithelial cells isolated from mouse mammary glands (n = 3 mice/group). H, Percent pSMAD2 + cells in breast ducts of women (n = 6 tissue samples/group). I, TGFβ1 expression in human breast ducts (n = 5 tissue samples/group). Data analyzed with Student's t test, mean ± SEM. Magnification bar = 50 µm
Article Snippet: For obesity studies, 3‐week‐old FVB/N or
Techniques: Control, Comparison, Expressing, Isolation